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Results for "

cyclic nucleotide phosphodiesterases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (10) Adenosine Deaminase (1) Adenosine Receptor (1) Apoptosis (1) Calcium Channel (2) Influenza Virus (1) Isotope-Labeled Compounds (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HCN Channel Cyclic GMP-AMP Synthase Phosphodiesterase (PDE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12085

Apremilast Maximum Cited Publications 6 Publications Verification CC-10004	Phosphodiesterase (PDE) Apoptosis TNF Receptor	Inflammation/Immunology
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-108974

Drotaverine hydrochloride	Phosphodiesterase (PDE) Calcium Channel
Drotaverine (hydrochloride) is a type *4 cyclic* nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC)** blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.

HY-163285

PDE3B-IN-1

Phosphodiesterase (PDE) Metabolic Disease

PDE3B-IN-1 is a selective inhibitor for phosphodiesterase PDE3B with an IMAP pIC₅₀ of 6.5 and a PDE3B/A selective index >300 .

PDE3B-IN-1	Phosphodiesterase (PDE)	Metabolic Disease
PDE3B-IN-1 is a selective inhibitor for phosphodiesterase PDE3B with an IMAP pIC₅₀ of 6.5 and a PDE3B/A selective index >300 .

HY-101661

Win 58237	Phosphodiesterase (PDE)	Cardiovascular Disease
Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with K_i of 170 nM for PDE V, possessing vasorelaxant activity.

HY-108623

Atizoram CP-80,633	Phosphodiesterase (PDE)	Inflammation/Immunology
Atizoram (CP-80,633), a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice .

HY-P2878

Phosphodiesterase PDE	Phosphodiesterase (PDE)	Neurological Disease
Phosphodiesterase (PDE) is an enzyme that can catalyze the hydrolysis of the 3' ring phosphate bond of cyclic nucleotides, and is often used in biochemical research. Phosphodiesterase acts as an important regulator of signal transduction mediated by the second messenger molecules cAMP and cGMP. According to their specificity to cyclic nucleotides, they can also be divided into different types, such as PDE1-PDE11, which also have certain potential in various diseases .

HY-N6781

Ophiobolin A	Phosphodiesterase (PDE)	Infection Cancer
Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC₅₀ value of 9 μM. Ophiobolin A antimicrobial and anticancer activity .

HY-B1726

Phenacaine Holocaine
Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca ²⁺-ATPase and cyclic nucleotide phosphodiesterases from brain and heart .

HY-108974S

Drotaverine-d10 hydrochloride	Isotope-Labeled Compounds Phosphodiesterase (PDE) Calcium Channel
Drotaverine-d₁₀ (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].

HY-B0128

Diphylline 1 Publications Verification Diprophylline	Adenosine Receptor Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide *phosphodiesterase* inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema .

HY-12085S

Apremilast-d5 CC-10004-d5
Apremilast-d₅ is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

HY-103160A

EHNA hydrochloride 3 Publications Verification	Adenosine Deaminase Phosphodiesterase (PDE) Influenza Virus	Infection Cardiovascular Disease Neurological Disease Cancer
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC₅₀=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC₅₀:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .

Phosphodiesterase PDE	Biochemical Assay Reagents
Phosphodiesterase (PDE) is an enzyme that can catalyze the hydrolysis of the 3' ring phosphate bond of cyclic nucleotides, and is often used in biochemical research. Phosphodiesterase acts as an important regulator of signal transduction mediated by the second messenger molecules cAMP and cGMP. According to their specificity to cyclic nucleotides, they can also be divided into different types, such as PDE1-PDE11, which also have certain potential in various diseases .

3′,5′-Cyclic nucleotide phosphodiesterase	Biochemical Assay Reagents
3′,5′-Cyclic nucleotide phosphodiesterase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

3′,5′-Cyclic nucleotide phosphodiesterase	Peptides	Others
3′,5′-Cyclic nucleotide phosphodiesterase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6781

Ophiobolin A	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Phosphodiesterase (PDE)
Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC₅₀ value of 9 μM. Ophiobolin A antimicrobial and anticancer activity .

Cat. No.	Product Name	Chemical Structure

HY-108974S

Drotaverine-d10 hydrochloride
Drotaverine-d₁₀ (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].

Drotaverine-d10 hydrochloride

Drotaverine-d₁₀ (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].

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